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Patents


KliniPharm owns unique patents that cover an array of technologies, methodologies, and devices directed at the isolation of distinct marine substances and their use in biomedical and cosmetic applications, skin care products, and nutritional supplements. KliniPharm's patented nanoparticle- and liposome-based drug delivery systems have demonstrated their superiority compared with standard pharmaceuticals and are therefore at the cutting edge of biopharmaceutics. To view a full listing of our patents, please visit the European Patent Office homepage.


Publications

KliniPharm scientists are leaders in marine biotechnology, biopharmaceutics, and pharmacology and author or co-author their research in professional journal articles, specialized book chapters, and proceedings in national and international conferences. Selections of our publications are listed below.


J Biomed Mater Res B Appl Biomater. 2016 Feb;104(2):308-15. doi: 10.1002/jbm.b.33370. Epub 2015 Mar 12. Biocompatibility of ;calcium phosphate bone cement with optimized mechanical properties. Palmer I1, Nelson J2, Schatton W3, Dunne NJ1, Buchanan FJ1, Clarke SA4.

Palmer I, Clarke AS, Nelson N, Schatton W, Dunne JN, Buchanan F. Identification of a suitable sterilisation method for collagen derived from a marine Demosponge. Int J Nano Biomaterials. 2012; 4(2):148-63.

Pergament V, Schatton W, Fotaki N. Study of release properties from marine sponge collagen coated formulations. Proc AAPS. 2011; 151:R6121

Nicklas M, Schatton W, Heinemann S, Hanke T, Kreuter J. Enteric coating derived from marine sponge collagen. Drug Dev Ind Pharm. 2009; 35(11):1384-8

Nicklas M, Schatton W, Heinemann S, Hanke T, Kreuter J. Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17beta-estradiol-hemihydrate. Drug Dev Ind Pharm. 2009; 35(9):1035-42

Heinemann S, Ehrlich H, Douglas T, Heinemann C, Worch H, Schatton W, Hanke T. Ultrastructural studies on the collagen of the marine sponge Chondrosia reniformis Nardo. Biomacromolecules. 2007; 8(11):3452-7

Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, Wijffels RH. Large-scale production of pharmaceuticals by marine sponges: sea, cell, or synthesis? Biotechnol Bioeng. 2005; 90(2):210-22

Ramm W, Schatton W, Wagner-Döbler I, Wray V, Nimtz M, Tokuda H, Enjyo F, Nishino H, Beil W, Heckmann R, Lurtz V, Lang S. Diglucosyl-glycerolipids from the marine sponge-associated Bacillus pumilus strain AAS3: their production, enzymatic modification and properties. Appl Microbiol Biotechnol. 2004; 64(4):497-504

Swatschek D, Schatton W, Müller W, Kreuter J. Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol. Eur J Pharm Biopharm. 2002; 54(2):125-33

Swatschek D, Schatton W, Kellermann J, Müller WE, Kreuter J. Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum. Eur J Pharm Biopharm. 2002; 53(1):107-13

Swatschek D, Schatton W, Müller WE, Kreuter J. Marine sponge collagen: isolation characterization and suitability for microparticle-preparation. Arch Pharm. 2000; 333(Supp/1):89

Müller WE, Wimmer W, Schatton W, Böhm M, Batel R, Filic Z. Initiation of an Aquaculture of Sponges for the Sustainable Production of Bioactive Metabolites in Open Systems: Example, Geodia cydonium. Mar Biotechnol (NY). 1999; 1(6):569-79

Freisleben, HJ, Bormann, J., Litzinger, D.C., Lehr, F., Rudolph, P., Schatton, W., and Huang, L. Toxicity and biodistribution of liposomes of the main phospholipid from the archaebacterium thermoplasma acidophilum in mice. J Liposome Res. 1995; 5(1):215-23

Beck PH, Kreuter J, Müller WEG, Schatton W. Improved peroral delivery of avarol with polybutylcyanoacrylate nanoparticles. Eur J Pharm Biopharm. 1994; 40(3):134-7

Müller WE, Ushijima H, Schröder HC, Forrest JM, Schatton WF, Rytik PG, Heffner-Lauc M. Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures. Eur J Pharmacol. 1993; 246(3):261-7




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